Thursday, August 25, 2011

One Word Can Save Your Life: No!

New research shows how some common tests and procedures aren’t just expensive, but can do more harm than good.

Tuesday, August 23, 2011

We are Christ-enabled.

Colossians 1:9-12 New Living Translation (NLT)

9 So we have not stopped praying for you since we first heard about you. We ask God to give you complete knowledge of his will and to give you spiritual wisdom and understanding. 10 Then the way you live will always honor and please the Lord, and your lives will produce every kind of good fruit. All the while, you will grow as you learn to know God better and better. 11 We also pray that you will be strengthened with all his glorious power so you will have all the endurance and patience you need. May you be filled with all the patience and endurance you need with joy, 12 always thanking the Father. He has enabled you to share in the inheritance that belongs to his people, who live in the light.

Eddy: “It is possible, -- yea, it is the duty and privilege of every child, man, and woman, -- to follow in some degree the example of the Master by the demonstration of Truth and Life, of health and holiness.”

Christly knowledge and pursuits propagate health, love, peace, patience, endurance and fulfillment.  Our Christ-spirit produces a nobler and rewarding standard of living.  The beneficial results and gratification that ensue from selfless, mutually supportive achievements outshine the pursuit of mere materiality.  Christly behavior compounds our health, enriches our relationships and improves our planet. 

Matthew 1:23 Today's New International Version (TNIV)

23 “The virgin will conceive and give birth to a son, and they will call him Immanuel” (which means “God with us”).

Eddy: “The Holy Ghost, or divine Spirit, overshadowed the pure sense of the Virgin-mother with the full recognition that being is Spirit.  The Christ dwelt forever an idea in the bosom of God, the divine Principle of the man, Jesus, and woman perceived this spiritual idea, though at first faintly developed.”

Our Christ-identity is a formidable expression of Spirit and dwells forever in the “bosom of God.”  Our MIND-sanctioned spiritual acuity (our pure, spiritual sense) enables us to recognize our spiritual wholeness and might.  This realization confronts and eradicates material challenges. 

Julio Rivas

Wednesday, August 17, 2011

1.  “Our Father which art in heaven.”

Dear Father-Principle and Mother-Love, you are the source of my identity, of my man-womanhood, of my perfect thoughts, of my health, of my entire being.  You are infinite good, the divine Ego.  You give me illimitable health, strength and confidence.  I am your spiritual and perfect son-daughter.  I live in your limitless love, power and harmony.  Your goodness is my hope and strength.  I am cradled and redeemed by your gentle, yet powerful, grace.  

2.  “Hallowed be thy name.”

Your nature (name) is incorporeal and divine because you are Spirit.  Because you are “All” your “spirit” is reflected in me, and throughout the universe.  I live in the peace, safety and holiness of your perfect Consciousness.

Lies, Damned Lies, and Medical Science

Much of what medical researchers conclude in their studies is misleading, exaggerated, or flat-out wrong. So why are doctors—to a striking extent—still drawing upon misinformation in their everyday practice? Dr. John Ioannidis has spent his career challenging his peers by exposing their bad science.

By David H. Freedman

Image credit: Robyn Twomey/Redux

In 2001, rumors were circulating in Greek hospitals that surgery residents, eager to rack up scalpel time, were falsely diagnosing hapless Albanian immigrants with appendicitis. At the University of Ioannina medical school’s teaching hospital, a newly minted doctor named Athina Tatsioni was discussing the rumors with colleagues when a professor who had overheard asked her if she’d like to try to prove whether they were true—he seemed to be almost daring her. She accepted the challenge and, with the professor’s and other colleagues’ help, eventually produced a formal study showing that, for whatever reason, the appendices removed from patients with Albanian names in six Greek hospitals were more than three times as likely to be perfectly healthy as those removed from patients with Greek names. “It was hard to find a journal willing to publish it, but we did,” recalls Tatsioni. “I also discovered that I really liked research.” Good thing, because the study had actually been a sort of audition. The professor, it turned out, had been putting together a team of exceptionally brash and curious young clinicians and Ph.D.s to join him in tackling an unusual and controversial agenda.

Last spring, I sat in on one of the team’s weekly meetings on the medical school’s campus, which is plunked crazily across a series of sharp hills. The building in which we met, like most at the school, had the look of a barracks and was festooned with political graffiti. But the group convened in a spacious conference room that would have been at home at a Silicon Valley start-up. Sprawled around a large table were Tatsioni and eight other youngish Greek researchers and physicians who, in contrast to the pasty younger staff frequently seen in U.S. hospitals, looked like the casually glamorous cast of a television medical drama. The professor, a dapper and soft-spoken man named John Ioannidis, loosely presided.

One of the researchers, a biostatistician named Georgia Salanti, fired up a laptop and projector and started to take the group through a study she and a few colleagues were completing that asked this question: were drug companies manipulating published research to make their drugs look good? Salanti ticked off data that seemed to indicate they were, but the other team members almost immediately started interrupting. One noted that Salanti’s study didn’t address the fact that drug-company research wasn’t measuring critically important “hard” outcomes for patients, such as survival versus death, and instead tended to measure “softer” outcomes, such as self-reported symptoms (“my chest doesn’t hurt as much today”). Another pointed out that Salanti’s study ignored the fact that when drug-company data seemed to show patients’ health improving, the data often failed to show that the drug was responsible, or that the improvement was more than marginal.

Salanti remained poised, as if the grilling were par for the course, and gamely acknowledged that the suggestions were all good—but a single study can’t prove everything, she said. Just as I was getting the sense that the data in drug studies were endlessly malleable, Ioannidis, who had mostly been listening, delivered what felt like a coup de grâce: wasn’t it possible, he asked, that drug companies were carefully selecting the topics of their studies—for example, comparing their new drugs against those already known to be inferior to others on the market—so that they were ahead of the game even before the data juggling began? “Maybe sometimes it’s the questions that are biased, not the answers,” he said, flashing a friendly smile. Everyone nodded. Though the results of drug studies often make newspaper headlines, you have to wonder whether they prove anything at all. Indeed, given the breadth of the potential problems raised at the meeting, can any medical-research studies be trusted?

That question has been central to Ioannidis’s career. He’s what’s known as a meta-researcher, and he’s become one of the world’s foremost experts on the credibility of medical research. He and his team have shown, again and again, and in many different ways, that much of what biomedical researchers conclude in published studies—conclusions that doctors keep in mind when they prescribe antibiotics or blood-pressure medication, or when they advise us to consume more fiber or less meat, or when they recommend surgery for heart disease or back pain—is misleading, exaggerated, and often flat-out wrong. He charges that as much as 90 percent of the published medical information that doctors rely on is flawed. His work has been widely accepted by the medical community; it has been published in the field’s top journals, where it is heavily cited; and he is a big draw at conferences. Given this exposure, and the fact that his work broadly targets everyone else’s work in medicine, as well as everything that physicians do and all the health advice we get, Ioannidis may be one of the most influential scientists alive. Yet for all his influence, he worries that the field of medical research is so pervasively flawed, and so riddled with conflicts of interest, that it might be chronically resistant to change—or even to publicly admitting that there’s a problem.

The city of Ioannina is a big college town a short drive from the ruins of a 20,000-seat amphitheater and a Zeusian sanctuary built at the site of the Dodona oracle. The oracle was said to have issued pronouncements to priests through the rustling of a sacred oak tree. Today, a different oak tree at the site provides visitors with a chance to try their own hands at extracting a prophecy. “I take all the researchers who visit me here, and almost every single one of them asks the tree the same question,” Ioannidis tells me, as we contemplate the tree the day after the team’s meeting. “‘Will my research grant be approved?’” He chuckles, but Ioannidis (pronounced yo-NEE-dees) tends to laugh not so much in mirth as to soften the sting of his attack. And sure enough, he goes on to suggest that an obsession with winning funding has gone a long way toward weakening the reliability of medical research.

He first stumbled on the sorts of problems plaguing the field, he explains, as a young physician-researcher in the early 1990s at Harvard. At the time, he was interested in diagnosing rare diseases, for which a lack of case data can leave doctors with little to go on other than intuition and rules of thumb. But he noticed that doctors seemed to proceed in much the same manner even when it came to cancer, heart disease, and other common ailments. Where were the hard data that would back up their treatment decisions? There was plenty of published research, but much of it was remarkably unscientific, based largely on observations of a small number of cases. A new “evidence-based medicine” movement was just starting to gather force, and Ioannidis decided to throw himself into it, working first with prominent researchers at Tufts University and then taking positions at Johns Hopkins University and the National Institutes of Health. He was unusually well armed: he had been a math prodigy of near-celebrity status in high school in Greece, and had followed his parents, who were both physician-researchers, into medicine. Now he’d have a chance to combine math and medicine by applying rigorous statistical analysis to what seemed a surprisingly sloppy field. “I assumed that everything we physicians did was basically right, but now I was going to help verify it,” he says. “All we’d have to do was systematically review the evidence, trust what it told us, and then everything would be perfect.”

It didn’t turn out that way. In poring over medical journals, he was struck by how many findings of all types were refuted by later findings. Of course, medical-science “never minds” are hardly secret. And they sometimes make headlines, as when in recent years large studies or growing consensuses of researchers concluded that mammograms, colonoscopies, and PSA tests are far less useful cancer-detection tools than we had been told; or when widely prescribed antidepressants such as Prozac, Zoloft, and Paxil were revealed to be no more effective than a placebo for most cases of depression; or when we learned that staying out of the sun entirely can actually increase cancer risks; or when we were told that the advice to drink lots of water during intense exercise was potentially fatal; or when, last April, we were informed that taking fish oil, exercising, and doing puzzles doesn’t really help fend off Alzheimer’s disease, as long claimed. Peer-reviewed studies have come to opposite conclusions on whether using cell phones can cause brain cancer, whether sleeping more than eight hours a night is healthful or dangerous, whether taking aspirin every day is more likely to save your life or cut it short, and whether routine angioplasty works better than pills to unclog heart arteries.

But beyond the headlines, Ioannidis was shocked at the range and reach of the reversals he was seeing in everyday medical research. “Randomized controlled trials,” which compare how one group responds to a treatment against how an identical group fares without the treatment, had long been considered nearly unshakable evidence, but they, too, ended up being wrong some of the time. “I realized even our gold-standard research had a lot of problems,” he says. Baffled, he started looking for the specific ways in which studies were going wrong. And before long he discovered that the range of errors being committed was astonishing: from what questions researchers posed, to how they set up the studies, to which patients they recruited for the studies, to which measurements they took, to how they analyzed the data, to how they presented their results, to how particular studies came to be published in medical journals.

This array suggested a bigger, underlying dysfunction, and Ioannidis thought he knew what it was. “The studies were biased,” he says. “Sometimes they were overtly biased. Sometimes it was difficult to see the bias, but it was there.” Researchers headed into their studies wanting certain results—and, lo and behold, they were getting them. We think of the scientific process as being objective, rigorous, and even ruthless in separating out what is true from what we merely wish to be true, but in fact it’s easy to manipulate results, even unintentionally or unconsciously. “At every step in the process, there is room to distort results, a way to make a stronger claim or to select what is going to be concluded,” says Ioannidis. “There is an intellectual conflict of interest that pressures researchers to find whatever it is that is most likely to get them funded.”

Perhaps only a minority of researchers were succumbing to this bias, but their distorted findings were having an outsize effect on published research. To get funding and tenured positions, and often merely to stay afloat, researchers have to get their work published in well-regarded journals, where rejection rates can climb above 90 percent. Not surprisingly, the studies that tend to make the grade are those with eye-catching findings. But while coming up with eye-catching theories is relatively easy, getting reality to bear them out is another matter. The great majority collapse under the weight of contradictory data when studied rigorously. Imagine, though, that five different research teams test an interesting theory that’s making the rounds, and four of the groups correctly prove the idea false, while the one less cautious group incorrectly “proves” it true through some combination of error, fluke, and clever selection of data. Guess whose findings your doctor ends up reading about in the journal, and you end up hearing about on the evening news? Researchers can sometimes win attention by refuting a prominent finding, which can help to at least raise doubts about results, but in general it is far more rewarding to add a new insight or exciting-sounding twist to existing research than to retest its basic premises—after all, simply re-proving someone else’s results is unlikely to get you published, and attempting to undermine the work of respected colleagues can have ugly professional repercussions.

In the late 1990s, Ioannidis set up a base at the University of Ioannina. He pulled together his team, which remains largely intact today, and started chipping away at the problem in a series of papers that pointed out specific ways certain studies were getting misleading results. Other meta-researchers were also starting to spotlight disturbingly high rates of error in the medical literature. But Ioannidis wanted to get the big picture across, and to do so with solid data, clear reasoning, and good statistical analysis. The project dragged on, until finally he retreated to the tiny island of Sikinos in the Aegean Sea, where he drew inspiration from the relatively primitive surroundings and the intellectual traditions they recalled. “A pervasive theme of ancient Greek literature is that you need to pursue the truth, no matter what the truth might be,” he says. In 2005, he unleashed two papers that challenged the foundations of medical research.

He chose to publish one paper, fittingly, in the online journal PLoS Medicine, which is committed to running any methodologically sound article without regard to how “interesting” the results may be. In the paper, Ioannidis laid out a detailed mathematical proof that, assuming modest levels of researcher bias, typically imperfect research techniques, and the well-known tendency to focus on exciting rather than highly plausible theories, researchers will come up with wrong findings most of the time. Simply put, if you’re attracted to ideas that have a good chance of being wrong, and if you’re motivated to prove them right, and if you have a little wiggle room in how you assemble the evidence, you’ll probably succeed in proving wrong theories right. His model predicted, in different fields of medical research, rates of wrongness roughly corresponding to the observed rates at which findings were later convincingly refuted: 80 percent of non-randomized studies (by far the most common type) turn out to be wrong, as do 25 percent of supposedly gold-standard randomized trials, and as much as 10 percent of the platinum-standard large randomized trials. The article spelled out his belief that researchers were frequently manipulating data analyses, chasing career-advancing findings rather than good science, and even using the peer-review process—in which journals ask researchers to help decide which studies to publish—to suppress opposing views. “You can question some of the details of John’s calculations, but it’s hard to argue that the essential ideas aren’t absolutely correct,” says Doug Altman, an Oxford University researcher who directs the Centre for Statistics in Medicine.

Still, Ioannidis anticipated that the community might shrug off his findings: sure, a lot of dubious research makes it into journals, but we researchers and physicians know to ignore it and focus on the good stuff, so what’s the big deal? The other paper headed off that claim. He zoomed in on 49 of the most highly regarded research findings in medicine over the previous 13 years, as judged by the science community’s two standard measures: the papers had appeared in the journals most widely cited in research articles, and the 49 articles themselves were the most widely cited articles in these journals. These were articles that helped lead to the widespread popularity of treatments such as the use of hormone-replacement therapy for menopausal women, vitamin E to reduce the risk of heart disease, coronary stents to ward off heart attacks, and daily low-dose aspirin to control blood pressure and prevent heart attacks and strokes. Ioannidis was putting his contentions to the test not against run-of-the-mill research, or even merely well-accepted research, but against the absolute tip of the research pyramid. Of the 49 articles, 45 claimed to have uncovered effective interventions. Thirty-four of these claims had been retested, and 14 of these, or 41 percent, had been convincingly shown to be wrong or significantly exaggerated. If between a third and a half of the most acclaimed research in medicine was proving untrustworthy, the scope and impact of the problem were undeniable. That article was published in the Journal of the American Medical Association.

Driving me back to campus in his smallish SUV—after insisting, as he apparently does with all his visitors, on showing me a nearby lake and the six monasteries situated on an islet within it—Ioannidis apologized profusely for running a yellow light, explaining with a laugh that he didn’t trust the truck behind him to stop. Considering his willingness, even eagerness, to slap the face of the medical-research community, Ioannidis comes off as thoughtful, upbeat, and deeply civil. He’s a careful listener, and his frequent grin and semi-apologetic chuckle can make the sharp prodding of his arguments seem almost good-natured. He is as quick, if not quicker, to question his own motives and competence as anyone else’s. A neat and compact 45-year-old with a trim mustache, he presents as a sort of dashing nerd—Giancarlo Giannini with a bit of Mr. Bean.

The humility and graciousness seem to serve him well in getting across a message that is not easy to digest or, for that matter, believe: that even highly regarded researchers at prestigious institutions sometimes churn out attention-grabbing findings rather than findings likely to be right. But Ioannidis points out that obviously questionable findings cram the pages of top medical journals, not to mention the morning headlines. Consider, he says, the endless stream of results from nutritional studies in which researchers follow thousands of people for some number of years, tracking what they eat and what supplements they take, and how their health changes over the course of the study. “Then the researchers start asking, ‘What did vitamin E do? What did vitamin C or D or A do? What changed with calorie intake, or protein or fat intake? What happened to cholesterol levels? Who got what type of cancer?’” he says. “They run everything through the mill, one at a time, and they start finding associations, and eventually conclude that vitamin X lowers the risk of cancer Y, or this food helps with the risk of that disease.” In a single week this fall, Google’s news page offered these headlines: “More Omega-3 Fats Didn’t Aid Heart Patients”; “Fruits, Vegetables Cut Cancer Risk for Smokers”; “Soy May Ease Sleep Problems in Older Women”; and dozens of similar stories.

When a five-year study of 10,000 people finds that those who take more vitamin X are less likely to get cancer Y, you’d think you have pretty good reason to take more vitamin X, and physicians routinely pass these recommendations on to patients. But these studies often sharply conflict with one another. Studies have gone back and forth on the cancer-preventing powers of vitamins A, D, and E; on the heart-health benefits of eating fat and carbs; and even on the question of whether being overweight is more likely to extend or shorten your life. How should we choose among these dueling, high-profile nutritional findings? Ioannidis suggests a simple approach: ignore them all.

For starters, he explains, the odds are that in any large database of many nutritional and health factors, there will be a few apparent connections that are in fact merely flukes, not real health effects—it’s a bit like combing through long, random strings of letters and claiming there’s an important message in any words that happen to turn up. But even if a study managed to highlight a genuine health connection to some nutrient, you’re unlikely to benefit much from taking more of it, because we consume thousands of nutrients that act together as a sort of network, and changing intake of just one of them is bound to cause ripples throughout the network that are far too complex for these studies to detect, and that may be as likely to harm you as help you. Even if changing that one factor does bring on the claimed improvement, there’s still a good chance that it won’t do you much good in the long run, because these studies rarely go on long enough to track the decades-long course of disease and ultimately death. Instead, they track easily measurable health “markers” such as cholesterol levels, blood pressure, and blood-sugar levels, and meta-experts have shown that changes in these markers often don’t correlate as well with long-term health as we have been led to believe.

On the relatively rare occasions when a study does go on long enough to track mortality, the findings frequently upend those of the shorter studies. (For example, though the vast majority of studies of overweight individuals link excess weight to ill health, the longest of them haven’t convincingly shown that overweight people are likely to die sooner, and a few of them have seemingly demonstrated that moderately overweight people are likely to live longer.) And these problems are aside from ubiquitous measurement errors (for example, people habitually misreport their diets in studies), routine misanalysis (researchers rely on complex software capable of juggling results in ways they don’t always understand), and the less common, but serious, problem of outright fraud (which has been revealed, in confidential surveys, to be much more widespread than scientists like to acknowledge).

If a study somehow avoids every one of these problems and finds a real connection to long-term changes in health, you’re still not guaranteed to benefit, because studies report average results that typically represent a vast range of individual outcomes. Should you be among the lucky minority that stands to benefit, don’t expect a noticeable improvement in your health, because studies usually detect only modest effects that merely tend to whittle your chances of succumbing to a particular disease from small to somewhat smaller. “The odds that anything useful will survive from any of these studies are poor,” says Ioannidis—dismissing in a breath a good chunk of the research into which we sink about $100 billion a year in the United States alone.

And so it goes for all medical studies, he says. Indeed, nutritional studies aren’t the worst. Drug studies have the added corruptive force of financial conflict of interest. The exciting links between genes and various diseases and traits that are relentlessly hyped in the press for heralding miraculous around-the-corner treatments for everything from colon cancer to schizophrenia have in the past proved so vulnerable to error and distortion, Ioannidis has found, that in some cases you’d have done about as well by throwing darts at a chart of the genome. (These studies seem to have improved somewhat in recent years, but whether they will hold up or be useful in treatment are still open questions.) Vioxx, Zelnorm, and Baycol were among the widely prescribed drugs found to be safe and effective in large randomized controlled trials before the drugs were yanked from the market as unsafe or not so effective, or both.

“Often the claims made by studies are so extravagant that you can immediately cross them out without needing to know much about the specific problems with the studies,” Ioannidis says. But of course it’s that very extravagance of claim (one large randomized controlled trial even proved that secret prayer by unknown parties can save the lives of heart-surgery patients, while another proved that secret prayer can harm them) that helps gets these findings into journals and then into our treatments and lifestyles, especially when the claim builds on impressive-sounding evidence. “Even when the evidence shows that a particular research idea is wrong, if you have thousands of scientists who have invested their careers in it, they’ll continue to publish papers on it,” he says. “It’s like an epidemic, in the sense that they’re infected with these wrong ideas, and they’re spreading it to other researchers through journals.”

Though scientists and science journalists are constantly talking up the value of the peer-review process, researchers admit among themselves that biased, erroneous, and even blatantly fraudulent studies easily slip through it. Nature, the grande dame of science journals, stated in a 2006 editorial, “Scientists understand that peer review per se provides only a minimal assurance of quality, and that the public conception of peer review as a stamp of authentication is far from the truth.” What’s more, the peer-review process often pressures researchers to shy away from striking out in genuinely new directions, and instead to build on the findings of their colleagues (that is, their potential reviewers) in ways that only seem like breakthroughs—as with the exciting-sounding gene linkages (autism genes identified!) and nutritional findings (olive oil lowers blood pressure!) that are really just dubious and conflicting variations on a theme.

Most journal editors don’t even claim to protect against the problems that plague these studies. University and government research overseers rarely step in to directly enforce research quality, and when they do, the science community goes ballistic over the outside interference. The ultimate protection against research error and bias is supposed to come from the way scientists constantly retest each other’s results—except they don’t. Only the most prominent findings are likely to be put to the test, because there’s likely to be publication payoff in firming up the proof, or contradicting it.

But even for medicine’s most influential studies, the evidence sometimes remains surprisingly narrow. Of those 45 super-cited studies that Ioannidis focused on, 11 had never been retested. Perhaps worse, Ioannidis found that even when a research error is outed, it typically persists for years or even decades. He looked at three prominent health studies from the 1980s and 1990s that were each later soundly refuted, and discovered that researchers continued to cite the original results as correct more often than as flawed—in one case for at least 12 years after the results were discredited.

Doctors may notice that their patients don’t seem to fare as well with certain treatments as the literature would lead them to expect, but the field is appropriately conditioned to subjugate such anecdotal evidence to study findings. Yet much, perhaps even most, of what doctors do has never been formally put to the test in credible studies, given that the need to do so became obvious to the field only in the 1990s, leaving it playing catch-up with a century or more of non-evidence-based medicine, and contributing to Ioannidis’s shockingly high estimate of the degree to which medical knowledge is flawed. That we’re not routinely made seriously ill by this shortfall, he argues, is due largely to the fact that most medical interventions and advice don’t address life-and-death situations, but rather aim to leave us marginally healthier or less unhealthy, so we usually neither gain nor risk all that much.

Medical research is not especially plagued with wrongness. Other meta-research experts have confirmed that similar issues distort research in all fields of science, from physics to economics (where the highly regarded economists J. Bradford DeLong and Kevin Lang once showed how a remarkably consistent paucity of strong evidence in published economics studies made it unlikely that any of them were right). And needless to say, things only get worse when it comes to the pop expertise that endlessly spews at us from diet, relationship, investment, and parenting gurus and pundits. But we expect more of scientists, and especially of medical scientists, given that we believe we are staking our lives on their results. The public hardly recognizes how bad a bet this is. The medical community itself might still be largely oblivious to the scope of the problem, if Ioannidis hadn’t forced a confrontation when he published his studies in 2005.

Ioannidis initially thought the community might come out fighting. Instead, it seemed relieved, as if it had been guiltily waiting for someone to blow the whistle, and eager to hear more. David Gorski, a surgeon and researcher at Detroit’s Barbara Ann Karmanos Cancer Institute, noted in his prominent medical blog that when he presented Ioannidis’s paper on highly cited research at a professional meeting, “not a single one of my surgical colleagues was the least bit surprised or disturbed by its findings.” Ioannidis offers a theory for the relatively calm reception. “I think that people didn’t feel I was only trying to provoke them, because I showed that it was a community problem, instead of pointing fingers at individual examples of bad research,” he says. In a sense, he gave scientists an opportunity to cluck about the wrongness without having to acknowledge that they themselves succumb to it—it was something everyone else did.

To say that Ioannidis’s work has been embraced would be an understatement. His PLoS Medicine paper is the most downloaded in the journal’s history, and it’s not even Ioannidis’s most-cited work—that would be a paper he published in Nature Genetics on the problems with gene-link studies. Other researchers are eager to work with him: he has published papers with 1,328 different co-authors at 538 institutions in 43 countries, he says. Last year he received, by his estimate, invitations to speak at 1,000 conferences and institutions around the world, and he was accepting an average of about five invitations a month until a case last year of excessive-travel-induced vertigo led him to cut back. Even so, in the weeks before I visited him he had addressed an AIDS conference in San Francisco, the European Society for Clinical Investigation, Harvard’s School of Public Health, and the medical schools at Stanford and Tufts.

The irony of his having achieved this sort of success by accusing the medical-research community of chasing after success is not lost on him, and he notes that it ought to raise the question of whether he himself might be pumping up his findings. “If I did a study and the results showed that in fact there wasn’t really much bias in research, would I be willing to publish it?” he asks. “That would create a real psychological conflict for me.” But his bigger worry, he says, is that while his fellow researchers seem to be getting the message, he hasn’t necessarily forced anyone to do a better job. He fears he won’t in the end have done much to improve anyone’s health. “There may not be fierce objections to what I’m saying,” he explains. “But it’s difficult to change the way that everyday doctors, patients, and healthy people think and behave.”

As helter-skelter as the University of Ioannina Medical School campus looks, the hospital abutting it looks reassuringly stolid. Athina Tatsioni has offered to take me on a tour of the facility, but we make it only as far as the entrance when she is greeted—accosted, really—by a worried-looking older woman. Tatsioni, normally a bit reserved, is warm and animated with the woman, and the two have a brief but intense conversation before embracing and saying goodbye. Tatsioni explains to me that the woman and her husband were patients of hers years ago; now the husband has been admitted to the hospital with abdominal pains, and Tatsioni has promised she’ll stop by his room later to say hello. Recalling the appendicitis story, I prod a bit, and she confesses she plans to do her own exam. She needs to be circumspect, though, so she won’t appear to be second-guessing the other doctors.

Tatsioni doesn’t so much fear that someone will carve out the man’s healthy appendix. Rather, she’s concerned that, like many patients, he’ll end up with prescriptions for multiple drugs that will do little to help him, and may well harm him. “Usually what happens is that the doctor will ask for a suite of biochemical tests—liver fat, pancreas function, and so on,” she tells me. “The tests could turn up something, but they’re probably irrelevant. Just having a good talk with the patient and getting a close history is much more likely to tell me what’s wrong.” Of course, the doctors have all been trained to order these tests, she notes, and doing so is a lot quicker than a long bedside chat. They’re also trained to ply the patient with whatever drugs might help whack any errant test numbers back into line. What they’re not trained to do is to go back and look at the research papers that helped make these drugs the standard of care. “When you look the papers up, you often find the drugs didn’t even work better than a placebo. And no one tested how they worked in combination with the other drugs,” she says. “Just taking the patient off everything can improve their health right away.” But not only is checking out the research another time-consuming task, patients often don’t even like it when they’re taken off their drugs, she explains; they find their prescriptions reassuring.

Later, Ioannidis tells me he makes a point of having several clinicians on his team. “Researchers and physicians often don’t understand each other; they speak different languages,” he says. Knowing that some of his researchers are spending more than half their time seeing patients makes him feel the team is better positioned to bridge that gap; their experience informs the team’s research with firsthand knowledge, and helps the team shape its papers in a way more likely to hit home with physicians. It’s not that he envisions doctors making all their decisions based solely on solid evidence—there’s simply too much complexity in patient treatment to pin down every situation with a great study. “Doctors need to rely on instinct and judgment to make choices,” he says. “But these choices should be as informed as possible by the evidence. And if the evidence isn’t good, doctors should know that, too. And so should patients.”

In fact, the question of whether the problems with medical research should be broadcast to the public is a sticky one in the meta-research community. Already feeling that they’re fighting to keep patients from turning to alternative medical treatments such as homeopathy, or misdiagnosing themselves on the Internet, or simply neglecting medical treatment altogether, many researchers and physicians aren’t eager to provide even more reason to be skeptical of what doctors do—not to mention how public disenchantment with medicine could affect research funding. Ioannidis dismisses these concerns. “If we don’t tell the public about these problems, then we’re no better than nonscientists who falsely claim they can heal,” he says. “If the drugs don’t work and we’re not sure how to treat something, why should we claim differently? Some fear that there may be less funding because we stop claiming we can prove we have miraculous treatments. But if we can’t really provide those miracles, how long will we be able to fool the public anyway? The scientific enterprise is probably the most fantastic achievement in human history, but that doesn’t mean we have a right to overstate what we’re accomplishing.”

We could solve much of the wrongness problem, Ioannidis says, if the world simply stopped expecting scientists to be right. That’s because being wrong in science is fine, and even necessary—as long as scientists recognize that they blew it, report their mistake openly instead of disguising it as a success, and then move on to the next thing, until they come up with the very occasional genuine breakthrough. But as long as careers remain contingent on producing a stream of research that’s dressed up to seem more right than it is, scientists will keep delivering exactly that.

“Science is a noble endeavor, but it’s also a low-yield endeavor,” he says. “I’m not sure that more than a very small percentage of medical research is ever likely to lead to major improvements in clinical outcomes and quality of life. We should be very comfortable with that fact.”

This article available online at:

Copyright © 2010 by The Atlantic Monthly Group. All Rights Reserved.

He that dwelleth in the secret place of the Most High shall abide under the shadow of the Almighty.  (21st Century King James Version)

I dwell in the exalting protection of SPIRIT-LIFE, way beyond the reach of material insinuations (impotent laws). 

2I will say of the LORD, "He is my refuge and my fortress; my God, in Him will I trust."

Evil – sin, illness, deficiency, failure and suffering -- cannot reach, penetrate nor disrupt my MIND-designed perfection and teeming opportunities.  I trust in MIND and enjoy its superabundant blessings.

Thursday, August 11, 2011

Our SOUL-produced richness of being.

Ruth 1:16 New Century Version (NCV)

16 But Ruth said, "Don't beg me to leave you or to stop following you. Where you go, I will go. Where you live, I will live. Your people will be my people, and your God will be my God.

Eddy: “Happiness is spiritual, born of Truth and Love.  It is unselfish; therefore it cannot exist alone, but requires all mankind to share it.”

When accosted by famine, death of loved ones, and loneliness Naomi and Ruth chose to work together for solutions, and they found them.  When we are confronted with setbacks and downfalls, we can unite our efforts and Soul’s wisdom and love will guide us to find new opportunities and resources. 

Romans 8:28 New International Version (NIV)

28 And we know that in all things God works for the good of those who love him, who[a] have been called according to his purpose.

Eddy: “Love inspires, illumines, designates, and leads the way.  Right motives pinions to thought, and strength and freedom to speech and action.”

GOOD/SOUL is always generating health, intelligence, talents, empathy, generosity and success in our spiritual composition.  Our purpose is to express it, which, in turn, honors SOUL/LOVE.  With SOUL’s profuse resources we can resolve all dilemmas. 


“Niebuhr, a towering presence in American intellectual life from the 1930s through the 1960s, thought deeply about the dilemmas confronting the U.S. as a con­sequence of its emergence as a global superpower. The truths he spoke are uncom­fortable ones.

“One persistent theme of Niebuhr’s writings on foreign policy concerns the dif­ficulty that Americans have in seeing themselves as they really are. ‘Perhaps the most significant moral characteristic of a nation,’ he declared in 1932, ‘is its hypocrisy.’ Niebuhr did not exempt his own nation from that judgment. The chief distinguishing feature of American hypocrisy lies in the conviction that America’s very founding was a providential act, both an expression of divine favor and a summons to serve as God’s chosen instrument.

The Anglo-American colonists settling these shores, according to Niebuhr, saw it as America’s purpose ‘to make a new beginning in a corrupt world.’ They believed ‘that we had been called out by God to create a new humanity.’ They believed further that this covenant with God marked America as a new Israel.

“As a chosen people possessing what Niebuhr referred to as a ‘Messianic con­sciousness,’ Americans came to see themselves as set apart, their motives irreproach­able, their actions not to be judged by standards applied to others.’ ‘Every nation has its own form of spiritual pride,’ Niebuhr observed in The Irony of American History. ‘Our version is that our nation turned its back on the vices of Europe and made a new beginning.’

Even after World War II, he wrote, the United States remained an adolescent nation, with illusions of childlike innocence.’ Indeed, the outcome of World War II, vaulting the United States to the apex of world power, seemed to affirm that the nation enjoyed God’s favor and was doing God’s work.

“Niebuhr had little patience for those who portray the United States as acting on God’s behalf. In that regard, the religiosity that seemingly forms such a durable element of the American national identity has a problematic dimension. ‘All men are naturally inclined to obscure the morally ambiguous element in their political cause by investing it with religious sanctity,’ observed Niebuhr. ‘This is why religion is more frequently a source of confusion than of light in the political realm.’ In the United States ‘the tendency to equate our political with our Christian convictions causes politics to generate idolatry.’ ”

A Niebuhr quote (in Partisan Review, May-June 1952) not cited by Bacevich is startlingly resonant 56 years later: “We are almost in greater peril from the foes within than from the foe without. The foes within are the spirits of hysteria, hatred, mistrust, and pride. We are engaged in such a perpetual liturgy of self-congratulation about the vaunted virtues and achievements of the ‘American Way of Life’ that we not only make ourselves odious to the world but also rob ourselves of the political wisdom required to wield power in a world which refuses to be made over into the image of America. . . . [Our] foreign policy has been frozen into inflexible rigidity, and our cherished liberties are being engulfed. History has not revealed a deeper irony than the destruction of the spirit of democratic liberty in the name of devotion to it.”

Bacevich (professor of History at Boston Univ.) again: “We should recall the warning with which Niebuhr concluded The Irony of American History. Should the U.S. perish, the prophet wrote, ‘the ruthlessness of the foe would be only the secondary cause of the disaster. The primary cause would be that the strength of a giant nation was directed by eyes too blind to see all the hazards of the struggle; and the blindness would be induced not by some accident of nature or history but by hatred and vainglory.’ ”

Bacevich comments on that last quote: “Change each ‘would be’ to ‘was’ and you have an inscription well-suited for the memorial that will no doubt be erected one day in Washington honoring those who sacrificed their lives in Iraq.” Inciden­tally, Bacevich’s son was killed in the Iraq war.

Historically Speaking (, January-February 2008

Here is a bit more enlightenment.

Forgive us, Father, for we have sinned

We also hear calls for repentance for the greed and pride and follies that have led us into current crises and quandaries. Here is more on national myopia, to the point as the season of Lent approaches. It’s a call by Kathleen O’Connor of Columbia Semi­nary in Decatur, Georgia for “repentance in first-person plural.” A good idea, since so much Lenten or other repentance-talk tends to isolate the individual. “Too often Lenten traditions reduce repentance to tiny shafts of personal failures, narrow it to fractures of the individual, to concern with foibles of each alone. Give up chocolate, eat less, or do something positive. Pray more faithfully, become more attentive to other people, be considerate of an irritating coworker. Too often Christian repentance remains focused on me, my improvement, and my personal relationship with God.

“Of course . . . any practice of repentance that awakens our spirits, increases prayer, and opens us up to God is good for the whole world. But even when observed with faithful motives and humble attitudes, such focus on the individual alone is myopic. It leaves our blind spots in place, accentuates our insularity, and ignores our national sins. I think we Christians in the United States suffer from spiritual myopia, from a near-sighted view of God’s world. We find it hard to see our lives in relation to life on the planet. What happens when Christians focus on the repentance of the individual is that our collective sin never appears before our eyes for repentance. Our national violence, preemptive warfare, assault on the environ­ment, our social bias, creed, exclusion of the poor and the different, our arrogance

toward other peoples, our overarching consumerism—these things remain invisible, out of sight, out of mind. When we repent of the sins that disturb our peace within the narrow walls of our cocoons, we remain unmoved by how the way we live harm’s God’s other peoples and God’s good earth. Maybe our arrogant insularity is our most pervasive collective sin.

“What would repentance look like if Christians in the United States began to think of ourselves as called to compassionate engagement with all of God’s people? Biblical repentance is not only the work of the first-person singular—of ‘I,’ ‘me,’ mine’; it is a call to all of us together. Biblical repentance asks for turning around in the first-person plural—of ‘we,’ ‘us,’ ‘our.’

“The prophet Amos calls for repentance in the first-person plural. His concerns are international, his vision is global. He hears the word of God with the force of a lion’s roar (3:8). That roaring voice blasts warnings upon all the people who do not live in the first-person plural, who do not recognize that the lives of others are sacred. . . . Amos tries to show his people that trust in anything or anyone other than God is false security. His calls for repentance do not use language of trust, but profound trust in God is implied. Our security rests not in our wealth, power, or armaments; it does not arise from bullying others into our service or doing our bidding; it does not come from amassing goods in our barns while others starve. True security lies in trust in the God who calls us together for right worship and for service in the world.

“Lenten repentance may not bring us to clarity about what to do; it may not even grant us a common interpretation of our sinful common life. But as long as we remain blind and insular, safe in our fortress world, focused on me alone, we cannot claim to be faithful worshippers of God. . . . Repentance in the plural can reinvigorate our identity as disciples of Jesus Christ, the Body of Christ in the world.”

Journal for Preachers, Lent 2008

I believe you will like this expression of Wisdom:

Gaining consciousness

From a 2005 commencement speech at Kenyon College, novelist David Foster Wal­lace, who committed suicide last September at age 46 after succumbing to a two-decade battle with depression: “In the day-to-day trenches of adult life, there is actu­ally no such thing as atheism. There is no such thing as not worshipping. Everybody worships. The only choice we get is what to worship. And an outstanding reason for choosing some sort of God or spiritual-type thing to worship—be it J.C. or Allah, be it Yahweh or the Wiccan mother-goddess or the Four Noble Truths or some invio­lable set of ethical principles—is that pretty much anything else you worship will eat you alive. If you worship money and things—if they are where you tap real mean­ing in life—then you will never have enough. Never feel you have enough. It’s the truth. Worship your own body and beauty and sexual allure and you will always feel ugly, and when time and age start showing, you will die a million deaths before they finally plant you.

 “On one level, we all know this stuff already—it’s been codified as myths, proverbs, clichés, bromides, epigrams, parables: the skeleton of every great story. The trick is keeping the truth up front in daily consciousness. Worship power, and you will feel weak and afraid, and you will need ever more power over others to keep the fear at bay. Worship your intellect, being seen as smart, and you will end up feeling stupid, a fraud, always on the verge of being found out.

“The insidious thing about these forms of worship is not that they’re evil or sinful; it is that they are unconscious. They are default settings. They’re the kind of

worship you just slip into, day after day, getting more and more selective about what you see and how you measure value, without ever being fully aware that that’s what you’re doing. And the world will not discourage you from operating on your default settings, because the world of men and money and power hums along quite nicely on the fuel of fear and contempt and frustration and the worship of self. Our own present culture has harnessed these forces in ways that have yielded extraordinary wealth and comfort and personal freedom. The freedom to be lords of our own tiny skull-sized kingdoms, alone at the center of all creation.

“That kind of freedom has much to recommend it. But of course there are all different kinds of freedom, and the kind that is most precious you will not hear

much talked about in the great outside world of winning and achieving and displaying. The really important kind of freedom involves attention, and awareness, and discipline, and effort, and being able truly to care about other people and to sacrifice for them, over and over, in myriad petty little unsexy ways, every day. That is real freedom. The alternative is unconsciousness, the default setting, the ‘rat race’—the constant gnawing sense of having had and lost some infinite thing.”

Wallace concluded his speech with a little story. “There are these two young fish swimming along, and they happen to meet an older fish swimming the other way, who nods at them and says, ‘Morning, boys, how’s the water?’ And the two young fish swim

on for a bit, and then eventually one of them looks over at the other and goes, ‘What the hell is water?’ [What I’m talking about] is simple awareness—aware­ness of what is so real and essential, so hidden in plain sight all around us, that we have to keep reminding ourselves, over and over: ‘This is water. This is water.’

“It is unimaginably hard to do this, to stay conscious and alive, day in and day out.” Sadly, we no longer have Wallace among us, but we can still learn from him.

The Wall Street Journal (, 9/19/08

Summary point: “The really important kind of freedom involves attention, and awareness, and discipline, and effort, and being able truly to care about other people and to sacrifice for them, over and over, in myriad petty little unsexy ways, every day.”


Seven Truths about Change to Lead By and Live By


By Rosabeth Moss Kanter

I call these the Change Agent Bumper Stickers. Here are seven universal sayings that can comfort and guide anyone engaged in the effort of setting a new direction, orchestrating innovation, establishing a culture, or changing behavior.

"Change is a threat when done to me, but an opportunity when done by me." I coined this truth in my book The Change Masters, which compared innovation-friendly and innovation-stifling corporate cultures, and then saw it in operation in personal relationships, too. Resistance is always greatest when change is inflicted on people without their involvement, making the change effort feel oppressive or constraining. If it is possible to tie change to things people already want, and give them a chance to act on their own goals and aspirations, then it is met with more enthusiasm and commitment. In fact, they then seek innovation on their own.

"A journey of a thousand miles starts with a single step." Big goals can seem overwhelming. The magnitude of the problem, the difficulty of the solutions, the length of the time horizon, and the number of action items can make change feel so complex that people feel paralyzed, and nothing happens. This saying from China's Chairman Mao is a reminder to get moving. Do something, get started, take the first steps however small they seem, and the journey is underway.

"If you don't know where you're going, any road will take you there." A clear destination is necessary to guide the journey of change. Many change efforts falter because of confusion over exactly where everyone is expected to arrive. In the children's book, Alice in Wonderland, Alice, who is confused anyway, asks the Cheshire cat which road she should take. The magical cat responds with this helpful reminder to pin down your goal first. Zoom in on the destination on your mental map, and then zoom out to pick the best path.

"Change a campaign, not a decision." How many people make vows to improve their diet and exercise, then feel so good about the decision that they reward themselves with ice cream and sit down to read a book? CEOs and senior executives make pronouncements about change all the time, and then launch programs that get ignored. To change behavior requires a campaign, with constant communication, tools and materials, milestones, reminders, and rewards.

"When you come to a fork in the road, take it." Baseball legend Yogi Berra was known for oddball sayings that contain gems. There is an aspect of change that involves trial and error. Fear of mistakes can sometimes leave paths unexplored. It's important to seize unexpected opportunities. Some sidelines are dead ends, but others might prove to be faster routes to the goals.

"Everything can look like a failure in the middle." I've observed this so often that I call it Kanter's Law. There are numerous roadblocks, obstacles, and surprises on the journey to change, and each one tempts us to give up. Give up prematurely, and the change effort is automatically a failure. Find a way around the obstacles, perhaps by making some tweaks in the plan, and keep going. Persistence and perseverance are essential to successful innovation and change.

"Be the change you seek to make in the world." Leaders must embody the values and principles they want other people to adopt. This famous Gandhi quote reminds us all — executives with associates, political leaders with followers, or parents with children — that one of the most important tasks is personal: to be a role model, exemplifying the best of what the change is all about.

Copyright © 2010 Harvard Business School Publishing. All rights reserved. Harvard Business Publishing is an affiliate of Harvard Business School.

I like this quote:

“Nothing worth doing can be achieved in

our lifetime; therefore we must be saved by hope. Nothing which is true or beautiful

or good makes complete sense in any immediate context of history; therefore

we must be saved by faith. Nothing we do, however virtuous, can be accomplished

alone; therefore we are saved by love. No virtuous act is quite as virtuous from the

standpoint of our friend or foe as it from our standpoint. Therefore we must be

saved by the final form of love, which is forgiveness.”

The Irony of American History by Reinhold Niebuhr

In proportion to how much we accept that these are healing qualities of Soul and feel/express them, they heal our lives/bodies.